12/31/2022 0 Comments Plos computational biology![]() ![]() Meanwhile, the annual American Society for Mass Spectrometry conference draws more than 6,000 attendees, and the society boasts 7,000 current members. ![]() At the Intelligent Systems for Molecular Biology (ISMB) conference, none of the designated subject areas for submitted manuscripts is relevant to mass spectrometry analysis, and over the last three years, a total of four mass spectometry papers were published at ISMB, each appearing in the “Other bioinformatics applications” category. PLoS Computational Biology published only two papers on the topic in 2010. Strikingly, however, relatively few bioinformatics researchers work on methods for analyzing mass spectrometry data. In both fields, the underlying technologies, along with the characteristics of the resulting data sets, change rapidly, requiring constant development of new analytical methods. And like short-read sequencing data, mass spectral data sets exhibit complex dependencies and patterns of missing data. Like a short-read sequencing machine, a mass spectrometer runs 24 hours a day, producing a huge quantity of data. Just as next-generation sequencing tehcnology is driving the current genomics boom, so improvements in tandem mass spectrometry technology are leading to more comprehensive and precise proteomics assays. But proteins are the molecular workhorses of the cell, and proteomics-the systematic study of the complete set of proteins expressed in a given cell, tissue, or organism-is poised to become the next hot topic. ![]() DNA gets a lot of attention these days, in whole genome sequencing projects, genome-wide association studies, and experiments measuring transcription factor binding, chromatin accessibility, DNA methylation, and histone modification profiles. ![]()
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